Modeling the Dynamics of T Helper 17 Induction and Differentiation
نویسندگان
چکیده
منابع مشابه
Modeling the Dynamics of T Helper 17 Induction and Differentiation
Background: CD4+ T cells play important roles in orchestrating immune responses, maintaining homeostasis and offering a functional control of immune responses. Depending on the cytokine milieu, a naïve CD4+ T cell differentiates into different phenotypes. The T helper 17 (Th17) phenotype remains controversial since it has been identified as an inductor of inflammation, but it contributes to the...
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Interleukin-17 (IL-17)-producing T helper cells (Th17 cells) constitute a lineage of CD4 effector T helper cells that is distinct from the Th1 and Th2 CD4 phenotypes. In humans, Th17 differentiation is induced in the presence of the cytokines IL-1 beta, IL-6 and TGF beta, whereas IL-23 maintains Th17 survival. Effector human Th17 cells express several cytokines and cell surface markers, includi...
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The third lineage of T helper subsets, Th17, has recently been identified as an IL- 17-producing CD4+ Th cell, and its functions and regulatory mechanisms have been extensively characterized in immune responses. Functional studies have provided evidence that Th17 cells are important for the modulation of autoimmune responses, such as chronic asthma, rheumatoid arthritis, inflammatory bowel dise...
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CD28/T cell receptor ligation activates the NF-κB signaling cascade during CD4 T cell activation. NF-κB activation is required for cytokine gene expression and activated T cell survival and proliferation. Recently, many reports showed that NF-κB activation is also involved in T helper (Th) cell differentiation including Th17 cell differentiation. In this review, we discuss the current literatur...
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sarcoidosis is a systemic granulomatous disorder of unidentified etiology, with a heterogeneous clinical presentation. it is characterized by a reduced delayed-type hypersensitivity to tuberculin and common antigens. the balance between th1, th17 and regulatory t(treg) cells controls t-cell proliferation and activation.the th17/treg ratio in the peripheral blood and bronchoalveolar lavage fluid...
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ژورنال
عنوان ژورنال: MOJ Immunology
سال: 2015
ISSN: 2373-4442
DOI: 10.15406/moji.2015.02.00038